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Using Big Data analytics to improve the treatment of all blood cancers


The HARMONY Alliance uses Big Data technologies to improve the treatment of blood cancers i.e. Hematologic Malignancies. These are cancers that affect the blood and lymphatic system. 

Acute Lymphoblastic Leukemia (ALL) | Acute Myeloid Leukemia (AML) | Acute Promyelocytic Leukemia (APL)Chronic Lymphocytic Leukemia (CLL) | Chronic Myeloid Leukemia (CML) | Essential Thrombocythemia (ET) | Hodgkin’s Lymphoma | Multiple Myeloma (MM) | Myelodysplastic Syndromes (MDS) | Myelofibrosis | Myeloproliferative disorders (MPN) |Non-Hodgkin Lymphoma (NHL) | Pediatric Hematologic Malignancies | Polycythaemia Vera (PV) | Waldenström Macroglobulinaemia (WM) | Other blood cancers.


Answering key outstanding questions
In recent decades, diagnosis and treatment of Hematologic Malignancies have substantially improved, but many remain incurable. The key outstanding questions in this field can only be answered by studying large numbers of patients. Therefore, the HARMONY Alliance has developed a unique research infrastructure to facilitate Big Data research in the field of Hematologic Malignancies.

Characterizing the molecular landscape of the various blood cancers | Understanding the pathophysiology of blood cancers | Identifying novel drug targets |Predicting disease course and drug response for subgroups of patients | Developing tools to select the most promising treatment strategy for a particular patient (i.e. personalized medicine).


Sharing data, exploration tools and knowledge
The HARMONY Big Data Platform assembles harmonized clinical data from over 165,000 European blood cancer patients (update December 2023). The associated data processing pipeline ensures data safety and quality, as well as patient privacy. The HARMONY Alliance has developed sophisticated data analytic tools, allowing scientists to answer research questions that cannot be addressed with other methods.



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