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HARMONY Multiple Myeloma Experts presenting at EMN2022

March 25, 2022 17:56 - x 00, 0 - 00:00

MM, Myeloma

HARMONY Partner European Myeloma Network (EMN) will organize its third meeting as a virtual event on April 6-9, 2022. 

HARMONY Multiple Myeloma Partners are involved in organizing EMN2022. At the meeting, Mattia D'Agostino of the University of Turin will present results on improving the prognostication of Multiple Myeloma using data from the EMN within the HARMONY Big Data Platform.



Multiple Myeloma

Multiple Myeloma (MM) is a malignancy of plasma cells that typically affects multiple sites within the bone marrow. The disease is often symptomless for a long time and already advanced at the time of diagnosis. Despite these recent advances, most patients eventually relapse, and the disease remains largely incurable. Mainly affecting elderly individuals, MM is the second most common hematologic malignancy in Europe.

An important HARMONY Multiple Myeloma Research Project, conducted through the HARMONY BigData Platform, is being coordinated by the EMN, and it involves many European sites. Study centers in locations including Italy, Spain, The Netherlands, Nordic countries, Germany and the UK have provided data for incorporation into the HARMONY MM datalake. The conduct of a study with such a large number of patients with MM is unprecedented in Europe.


HARMONY Big Data Platform

The HARMONY Alliance aims to improve the care for people with MM and other Hematologic Malignancies. With a data lake (>100,000 patient data sets identified) and associated advanced big data analytic tools, HARMONY’s research infrastructure is uniquely suited to address key outstanding questions about Hematologic Malignancies. Research teams are using these resources to answer critical questions that cannot be addressed with other methods.


Prognostic factors

On 7 April 2022 at 16:00 hrs (session VI), HARMONY Expert Mattia D'Agostino, University of Turin, will give a presentation entitled ‘'Cytogenetic risk factors: is it time for revision? Detection and impact of 1q & R2-ISS'’. D'Agostino is leading the HARMONY Research Project on the revision of the international staging system for MM, which is being conducted through the HARMONY Big Data Platform. Clinical outcomes for patients with MM vary greatly, with survival ranging from a few months to more than ten years. The improved risk stratification model developed by D’Agostino and colleagues facilitates a more precise estimate of patients' prognosis at the time of MM diagnosis. This may facilitate tailoring MM treatments according to individual risks.


About the EMN

In 2005, a group of European hematologists joined forces to increase their understanding of MM and develop effective research projects and clinical trials. These efforts resulted in the establishment of the European Myeloma Network (EMN), a non-profit organization. EMN is a HARMONY Partner and coordinates an important MM research project within HARMONY, involving many European partners.



#bigdataforbloodcancer: Accelerating Better and Faster Treatment for Patients with Hematologic Malignancies.

The HARMONY Alliance (HARMONY and HARMONY PLUS) is a public-private partnership for Big Data in Hematology. Our mission is to unlock and spread valuable knowledge on hematologic malignancies (blood cancers) among many stakeholders, with the goal to harness and mine Big Data to speed up the development of improved treatments for patients and more effective treatment strategies.


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